Chromatin Structure & Function Lab

schalch lab website


Go to selected publications

  • Leopold K., Stirpe A. and Schalch, T. (2019). Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Genes & Development, Published in Advance, doi: 10.1101/gad.320440.11. Open Access Article
  • Jørgensen, M.M., Ekundayo, B., Zaratiegui, M., Skriver, K., Thon, G., and Schalch, T. (2018). Structure of the replication regulator Sap1 reveals functionally important interfaces. Scientific Reports 8, 10930. Open Access Article
  • Ekundayo, B., Richmond, T.J., and Schalch, T. (2017). Capturing structural heterogeneity in chromatin fibers. Journal of Molecular Biology 429, 3031-3042. Article, UNIGE archives
  • Grimaldi, M., Karaca, M., Latini, L., Brioudes, E., Schalch, T., and Maechler, P. (2017). Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia. Human Molecular Genetics 26, 3453–3465. Article
  • Schalch, T. (2017). Higher order chromatin structures are taking shape. Zeitschrift für Medizinische Physik 27, 75–77. Article
  • Schalch, T., and Steiner, F.A. (2017). Structure of centromere chromatin: from nucleosome to chromosomal architecture. Chromosoma 126, 443–455.
  • Job, G., Brugger, C., Xu, T., Lowe, B.R., Pfister, Y., Qu, C., Shanker, S., Baños Sanz, J.I., Partridge, J.F. and Schalch, T. (2016). SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Molecular Cell, 62, 207–221. Article
  • Binkert, M., Crocco, C.D., Ekundayo, B., Lau, K., Raffelberg, S., Tilbrook, K., Yin,R., Chappuis, R., Schalch, T. and Ulm, R. (2016). Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8. BMC Plant Biol. 16, 42. Article
  • Castonguay E., White S.A., Kagansky A., St-Cyr D.J., Castillo A.G., Brugger C., White R., Bonilla C., Spitzer M., Earnshaw W.C., Schalch T., Ekwall K., Tyers M., Allshire R. (2015). Pan-Species Small Molecule Disruptors of Heterochromatin-Mediated Transcriptional Gene Silencing. Molecular and Cellular Biology, 35, 662-674. Article
  • Kuscu, C., Zaratiegui, M., Kim, H.S., Wah, D.A. Martienssen, R.A., Schalch, T. and Joshua-Tor, L.(2014). CRL4-like Clr4 Complex in Schizosaccharomyces Pombe Depends on an Exposed Surface of Dos1 for Heterochromatin Silencing. PNAS, 111, 1795-1800. Article
  • Paul, S., Kuo, A., Schalch, T., Vogel, H., Joshua-Tor, L., McCombie, W.R., Gozani, O., Hammell, M., and Mills, A.A. (2013). Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression. Cell Reports 3, 92–102. Article
  • Schalch, T., Job, G., Shanker, S , Partridge, J. F., Joshua-Tor, L. (2011). The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural and Molecular Biology 18, 1351–7. Article
  • Schalch, T., Job, G., Noffsinger, V. J., Shanker, S., Kuscu, C., Joshua-Tor, L., and Partridge, J. F. (2009). High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Molecular Cell 34, 36–46. Article
  • Bieniossek, C., Schalch, T., Bumann, M., Meister, M., Meier, R., and Baumann, U. (2006). The molecular architecture of the metalloprotease FtsH. PNAS 103, 3066–71. Article
  • Schalch, T., Duda, S., Sargent, D. F., and Richmond, T. J. (2005). X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature 436, 138–41. Article
  • Dorigo, B., Schalch, T., Kulangara, A., Duda, S., Schroeder, R. R., and Richmond, T. J. (2004). Nucleosome arrays reveal the two-start organization of the chromatin fiber. Science 306, 1571–3. Article
  • Dorigo, B., Schalch, T., Bystricky, K., and Richmond, T. J. (2003). Chromatin fiber folding: requirement for the histone H4 N-terminal tail. Journal of Molecular Biology 327, 85–96. Article