Chromatin Structure & Function Lab

Schalch Lab Website

Publications

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  1. Moraru, M and Schalch, T. (2019). Chromatin fiber structural motifs as regulatory hubs of genome function? Essays In Biochemistry, EBC20180065. Open Access Article
  2. Leopold K., Stirpe A. and Schalch, T. (2019). Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Genes & Development, Published in Advance, doi: 10.1101/gad.320440.11. Open Access Article
  3. Jørgensen, M.M., Ekundayo, B., Zaratiegui, M., Skriver, K., Thon, G., and Schalch, T. (2018). Structure of the replication regulator Sap1 reveals functionally important interfaces. Scientific Reports 8, 10930. Open Access Article
  4. Ekundayo, B., Richmond, T.J., and Schalch, T. (2017). Capturing structural heterogeneity in chromatin fibers. Journal of Molecular Biology 429, 3031-3042. Article, UNIGE archives
  5. Grimaldi, M., Karaca, M., Latini, L., Brioudes, E., Schalch, T., and Maechler, P. (2017). Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia. Human Molecular Genetics 26, 3453–3465. Article
  6. Schalch, T. (2017). Higher order chromatin structures are taking shape. Zeitschrift für Medizinische Physik 27, 75–77. Article
  7. Schalch, T., and Steiner, F.A. (2017). Structure of centromere chromatin: from nucleosome to chromosomal architecture. Chromosoma 126, 443–455.
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  8. Job, G., Brugger, C., Xu, T., Lowe, B.R., Pfister, Y., Qu, C., Shanker, S., Baños Sanz, J.I., Partridge, J.F. and Schalch, T. (2016). SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules. Molecular Cell, 62, 207–221. Article
  9. Binkert, M., Crocco, C.D., Ekundayo, B., Lau, K., Raffelberg, S., Tilbrook, K., Yin,R., Chappuis, R., Schalch, T. and Ulm, R. (2016). Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8. BMC Plant Biol. 16, 42. Article
  10. Castonguay E., White S.A., Kagansky A., St-Cyr D.J., Castillo A.G., Brugger C., White R., Bonilla C., Spitzer M., Earnshaw W.C., Schalch T., Ekwall K., Tyers M., Allshire R. (2015). Pan-Species Small Molecule Disruptors of Heterochromatin-Mediated Transcriptional Gene Silencing. Molecular and Cellular Biology, 35, 662-674. Article
  11. Kuscu, C., Zaratiegui, M., Kim, H.S., Wah, D.A. Martienssen, R.A., Schalch, T. and Joshua-Tor, L.(2014). CRL4-like Clr4 Complex in Schizosaccharomyces Pombe Depends on an Exposed Surface of Dos1 for Heterochromatin Silencing. PNAS, 111, 1795-1800. Article
  12. Paul, S., Kuo, A., Schalch, T., Vogel, H., Joshua-Tor, L., McCombie, W.R., Gozani, O., Hammell, M., and Mills, A.A. (2013). Chd5 Requires PHD-Mediated Histone 3 Binding for Tumor Suppression. Cell Reports 3, 92–102. Article
  13. Schalch, T., Job, G., Shanker, S , Partridge, J. F., Joshua-Tor, L. (2011). The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS. Nature Structural and Molecular Biology 18, 1351–7. Article
  14. Schalch, T., Job, G., Noffsinger, V. J., Shanker, S., Kuscu, C., Joshua-Tor, L., and Partridge, J. F. (2009). High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Molecular Cell 34, 36–46. Article
  15. Bieniossek, C., Schalch, T., Bumann, M., Meister, M., Meier, R., and Baumann, U. (2006). The molecular architecture of the metalloprotease FtsH. PNAS 103, 3066–71. Article
  16. Schalch, T., Duda, S., Sargent, D. F., and Richmond, T. J. (2005). X-ray structure of a tetranucleosome and its implications for the chromatin fibre. Nature 436, 138–41. Article
  17. Dorigo, B., Schalch, T., Kulangara, A., Duda, S., Schroeder, R. R., and Richmond, T. J. (2004). Nucleosome arrays reveal the two-start organization of the chromatin fiber. Science 306, 1571–3. Article
  18. Dorigo, B., Schalch, T., Bystricky, K., and Richmond, T. J. (2003). Chromatin fiber folding: requirement for the histone H4 N-terminal tail. Journal of Molecular Biology 327, 85–96. Article